Project Details
Abstract
研究ATP13A2基因突變造成早發性第九型帕金森病的分子機轉至關重要，目前仍有無能治癒帕金森病的藥物。探討ATP13A2突變引起帕金森病的病理機轉有助於開發改善帕金森病的治療方法。計畫中的研究成果不僅有助於解開ATP13A2突變的致病機轉，也有助於神經保護分子的開發。計畫中開發的外泌體生物標記，可能應用於帕金森病的早期診斷和預後評估。計畫中也能了解小分子A11和TML-6對於帕金森病的療效。
Project IDs
Project ID:PC11407-3643
External Project ID:NSTC114-2314-B182-017
External Project ID:NSTC114-2314-B182-017
| Status | Active |
|---|---|
| Effective start/end date | 01/08/25 → 31/07/26 |
Keywords
- Parkinson’s disease
- PARK9
- ATP13A2
- ATP13A2 mutation knockin mice
- iPSCs
- early endosome pathway
- autophagy-endolysosomal system
- α-synuclein
- cholinergic system
- polyamine
- neuroinflammation
- BBB dysfunction
- biochiop
- exsosome
- A11
- TML-6.
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.