Synthesis and Chemical Modification of Natural Product Derivatives against Cathepsin C

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

本計畫在學術上可建立新型cathepsin C抑制劑研究平台,可作為中藥科學化、藥物化學、藥理等研究之應用。在經濟上所開發的先導化合物,可進行技術移轉,提供製藥生技產業進行相關新藥開發。在社會發展上隨著COVID-19的流感化與空汙惡化,急性呼吸窘迫症候群相關肺部疾病的發生率增加,故本計畫的執行對於相關藥物的開發有其重要性。

Project IDs

Project ID:PC11308-2338
External Project ID:NSTC112-2320-B182-019-MY3
StatusActive
Effective start/end date01/08/2431/07/25

Keywords

  • neutrophil serine proteases
  • cathepsin C
  • Acute respiratory distress syndrome (ARDS)
  • Coptis chinensis
  • jatrorrhizine

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