Synthesis and Studies of the Biorecognized, Acid and Photo- Dual Responsive Polysaccharide Drug Carriers

  • Lee, Ren-Shen (PI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

As one of the main approaches for the eating cancer, chemotherapy is faced with an inevitable challenge. Drug delivery using polymers has garnered significant attention in pharmaceutical research since polymer nanoassemblies were shown to carry various therapeutic agents to target dieses sites in the body. Much recent work has focused on developing polymer drug carriers (Temperature, pH). The tumor tissue has lower pH and higher temperature than normal tissue, polymer micelles that are responsive to environmental changes in pH or external stimuli such as light have been developed. Among the available stimuli, light is a particularly attractive trigger for use in controlling the behavior of biomaterials. In this project, the multifunctional, pH/photo-trigger drug delivery systems were developed with polysaccharide (dextran) as a hydrophilic segment and polyester containing pH/photo-trigger as a hydrophobic segment. Polysaccharides encompass many brilliant physical, chemical, and physiological properties, such as excellent biocompatibility, biodegradable and polyfunctionality for facile chemical decoration. Acidic-labile acetal and photo-cleavable o-nitrobenzyl moieties were grafted to main chain of the polysaccharide block to achieve micelle disruption upon pH change and irradiation.

Project IDs

Project ID:PB10507-2472
External Project ID:MOST105-2221-E182-080
StatusFinished
Effective start/end date01/08/1631/07/17

Keywords

  • Muti-functional drug delivery
  • polysaccharide
  • acid/photo-labile
  • polyester

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.