Synthesis and Studies the Bio-Recognizable/Bioreducible-Resposive/Photocleavable Targeted Drug Delivery System

  • Lee, Ren-Shen (PI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


The ideal drug delivery system combines targeted delivery (i.e. a strong affinity for target cells or target tissue) with controlled release (i.e. release triggered by a characteristic feature of the diseased cells) such that the drug is delivered and release in a selective and discriminatory fashion. Cell surface carbohydrates from glycoproteins and glycolipids play a key role as recognition sites between cells, but also between cells and microorganisms. The recognition mechanisms are based on specific interactions between the saccharose residues and protein receptors, the so-called “lectins”. Bioreducible-responsive and photo-responsive amphiphilic block copolymers self-assembling into well-defined nanostructures are a subject of high scientific multidisciplinary interest. These nanostructures are seen as excellent candidates for the encapsulation and controlled delivery of drugs and other biological compounds. Recently, there has been a growing interest in bioreducible-responsive and photo-responsive nanostructures which are able to degrade the main chain upon light exposure and in the cancer cell with high glutathione (GSH) concentration. The use of light as an external trigger is highly desirable since it allows precise temporal (when the light source is switched on) and spatial (where the light is directed to) control as opposed to other stimuli. In this proposal, we will study the synthesis of a novel amphiphilic block copolymer with multi-functionalized such as molecular recognition, bioreducible-responsive, photo-responsive and biodegradable properties. Glyco-ONB-s-s-PXCL copolymers will be synthesized via a combination of ROP and nucleophilic reaction from a initiator hydroxypropyl-mercaptopyridine with functional α-XCL, and then coupling the 5-hydroxy-2-nitro-benzyl thiol as the photo-cleavable molecule. At the same time, we will identify the structure with FT-IR and NMR, characterize the physicochemical properties by fluorescence spectroscopy and UV-Vis, and evaluate the possibility can be used in targeted drug delivery system by light exposure, or slowly under the effect of reduction, or with a combined fast-slow rate profile using the two stimuli.

Project IDs

Project ID:PB10408-5703
External Project ID:MOST104-2221-E182-061
Effective start/end date01/08/1531/07/16


  • Targeted drug delivery
  • Bioreducible-responsive
  • Photo-responsive
  • Functional polyester
  • Cellular uptake


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