Synthesis of Novel Biodegradable Temperature/Ph Dual Sensitive Materials and Their Applications Study

  • Lee, Ren-Shen (PI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


Recently, much effort has been directed to the development of intelligent materials that respond to internal or external stimuli, in particular, temperature and pH. Stimuli-sensitive materials have emerged as novel programmable delivery system. However, PNiPPAm and its copolymers have been found to non-biodegradable, presenting and obstacle to their application as implantable biomaterials. The aim of this project is synthesis the novel biodegradable thermo- and pH-responsive materials. In the first year, we will develop the novel full biodegradable PNRHpr-b-PMCC temperature/ pH-responsive block copolymers with PNRHpr as the temperature-responsive segment, and PMCC as the pH-responsive segment. In the second year, we will develop the novel biodegradable PNRHpr-b-(PαN3CL-g-alkyne) block-graft copolymers coupling the bioactive molecules to the polymer by click reaction. 1H-NMR、FTIR and gel-permeation chromatograph (GPC) were used to theses copolymers. The lower critical solution temperature (LCST) will measure by UV-Vis with temperature control.

Project IDs

Project ID:PB10007-0375
External Project ID:NSC100-2221-E182-016
Effective start/end date01/08/1131/07/12


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