Project Details
Abstract
Recently, much effort has been directed to the development of intelligent materials that respond to internal or external stimuli, in particular, temperature and pH. Stimuli-sensitive materials have emerged as novel programmable delivery system. However, PNiPPAm and its copolymers have been found to non-biodegradable, presenting and obstacle to their application as implantable biomaterials.
The aim of this project is synthesis the novel biodegradable thermo- and pH-responsive materials. In the first year, we will develop the novel full biodegradable PNRHpr-b-PMCC temperature/ pH-responsive block copolymers with PNRHpr as the temperature-responsive segment, and PMCC as the pH-responsive segment. In the second year, we will develop the novel biodegradable PNRHpr-b-(PαN3CL-g-alkyne) block-graft copolymers coupling the bioactive molecules to the polymer by click reaction. 1H-NMR、FTIR and gel-permeation
chromatograph (GPC) were used to theses copolymers. The lower critical solution temperature (LCST) will measure by UV-Vis with temperature control.
Project IDs
Project ID:PB10007-0375
External Project ID:NSC100-2221-E182-016
External Project ID:NSC100-2221-E182-016
Status | Finished |
---|---|
Effective start/end date | 01/08/11 → 31/07/12 |
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