Synthesis of the Biodegradable Ph-Sensitive Drug Targated Carrier Poly(Pseudoamino Acid) Nano-Materials and Their Applications Studies

The ideal drug delivery system combines targeted delivery (i.e. a strong affinity for target cells or target tissue) with controlled release (i.e. release triggered by a characteristic feature of the diseased cells) such that the drug is delivered and release in a selective and discriminatory fashion. Cell surface carbohydrates from glycoproteins and glycolipids play a key role as recognition sites between cells, but also between cells and microorganisms. The recognition mechanisms are based on specific interactions between the saccharose residues and protein receptors, the so-called “lectins”. In this proposal, we will study the synthesis of sugar-functionalized poly(pseudo amino acid ) including the coupling of alkynyl-sugar with azido-poly(pseudo amino acid) by click reaction in the first year project. At the same time, we will identify the structure with FT-IR and NMR, characterize the physicochemical properties by fluorescence spectroscopy and UV-Vis, and evaluate the possibility can be used in targeted drug delivery system. In the second year, we will study the synthesis of sugar-functionalized poly(pseudo amino acid) block functional poly(-caprolactone) by the ring-opening polymerization and click reaction. The structures of graft-block copolymers will be determined by FT-IR and NMR spectroscopy. The micelle properties will be characterized by fluorescence and UV-Vis spectroscopy, and evaluate the possibilities of applying the above-mentioned polymers to targeted drug delivery system.

Project ID:PB10107-1752
External Project ID:NSC101-2221-E182-009