Synthesis of the Biodegradable Photo-Responsive Drug Carrier with Fluorescence and Targeting Moieties for Controlled Release

  • Lee, Ren-Shen (PI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


Amphiphilic photo-cleavable block copolymers containing 5-hydroxy-2-nitrobenzyl alcohol, a photodegradable linker and a junction point between the hydrophilic β-cyclodextrin (β-CD) and hydrophobic poly(4-substituted-?-caprolactone) (PXCLn) chain, were synthesized through a combination of ring-opening polymerization and nucleophilic substitution reactions. When exposed to ultraviolet irradiation, the polymer demonstrated major structural changes. The β-CD -terminated-ONB-PXCLn polymer formed micelles in the aqueous phase. The critical micelle concentration ranged from 3.93 to 43.75 mg L-1. The drug -loading content and drug entrapment efficiency of the modified β-CD were higher than those of the parent β-CD. The nanoparticles exhibited nonsignificant toxicity at concentrations up to 1000 μg mL-1. Results of confocal microscopy and flow cytometry demonstrated that the uptake of doxorubicin -incorporated micelles by HeLa cells was faster than that of free doxorubicin within the first 5 min.

Project IDs

Project ID:PB10308-2731
External Project ID:MOST103-2221-E182-071
Effective start/end date01/08/1431/07/15


  • Targeted drug delivery
  • Photo-responsive
  • Functional polyester /carbonate
  • Click reaction
  • Cellular uptake


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