Synthesis Photo-Responsive Biodegradable Targeted Drug-Carrier and Their Applications Studies

  • Lee, Ren-Shen (PI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

The ideal drug delivery system combines targeted delivery (i.e. a strong affinity for target cells or target tissue) with controlled release (i.e. release triggered by a characteristic feature of the diseased cells) such that the drug is delivered and release in a selective and discriminatory fashion. Cell surface carbohydrates from glycoproteins and glycolipids play a key role as recognition sites between cells, but also between cells and microorganisms. The recognition mechanisms are based on specific interactions between the saccharose residues and protein receptors, the so-called “lectins”. Stimuli-responsive amphiphilic block copolymers self-assembling into well-defined nanostructures are a subject of high scientific multidisciplinary interest. These nanostructures are seen as excellent candidates for the encapsulation and controlled delivery of drugs and other biological compounds. The underlying strategy beyond these systems is the use of an external stimulus (such as pH, temperature, chemical stimulus, etc.) to induce destabilization of micelles or vesicles, hence triggering the release of a payload. Recently, there has been a growing interest in photoresponsive nanostructures which are able to degrade upon light exposure. The use of light as an external trigger is highly desirable since it allows precise temporal (when the light source is switched on) and spatial (where the light is directed to) control as opposed to other stimuli. In this proposal, we will study the synthesis of a novel amphiphilic block copolymer containing a photodegradable linker as a junction point between hydrophilic (saccharose) and hydrophobic (substituted polycaprolactone) chains is presented. Sugar-HNB-PXCL block copolymers will be synthesize via a combination of ROP and click reaction from a difunctional photoresponsive initiator HNB. At the same time, we will identify the structure with FT-IR and NMR, characterize the physicochemical properties by fluorescence spectroscopy and UV-Vis, and evaluate the possibility can be used in targeted drug delivery system.

Project IDs

Project ID:PB10207-1919
External Project ID:NSC102-2221-E182-068
StatusFinished
Effective start/end date01/08/1331/07/14

Keywords

  • Targeted drug delivery
  • Photo-responsive
  • Polyester
  • Click reaction
  • Cellular uptake

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