Project Details
Abstract
The ideal drug delivery system combines targeted delivery (i.e. a strong affinity for target
cells or target tissue) with controlled release (i.e. release triggered by a characteristic feature
of the diseased cells) such that the drug is delivered and release in a selective and
discriminatory fashion.
Cell surface carbohydrates from glycoproteins and glycolipids play a key role as
recognition sites between cells, but also between cells and microorganisms. The recognition
mechanisms are based on specific interactions between the saccharose residues and protein
receptors, the so-called “lectins”.
Stimuli-responsive amphiphilic block copolymers self-assembling into well-defined
nanostructures are a subject of high scientific multidisciplinary interest. These nanostructures
are seen as excellent candidates for the encapsulation and controlled delivery of drugs and
other biological compounds. The underlying strategy beyond these systems is the use of an
external stimulus (such as pH, temperature, chemical stimulus, etc.) to induce destabilization
of micelles or vesicles, hence triggering the release of a payload. Recently, there has been a
growing interest in photoresponsive nanostructures which are able to degrade upon light
exposure. The use of light as an external trigger is highly desirable since it allows precise
temporal (when the light source is switched on) and spatial (where the light is directed to)
control as opposed to other stimuli.
In this proposal, we will study the synthesis of a novel amphiphilic block copolymer
containing a photodegradable linker as a junction point between hydrophilic (saccharose) and
hydrophobic (substituted polycaprolactone) chains is presented. Sugar-HNB-PXCL block
copolymers will be synthesize via a combination of ROP and click reaction from a difunctional photoresponsive initiator HNB. At the same time, we will identify the structure
with FT-IR and NMR, characterize the physicochemical properties by fluorescence spectroscopy and UV-Vis, and evaluate the possibility can be used in targeted drug delivery system.
Project IDs
Project ID:PB10207-1919
External Project ID:NSC102-2221-E182-068
External Project ID:NSC102-2221-E182-068
Status | Finished |
---|---|
Effective start/end date | 01/08/13 → 31/07/14 |
Keywords
- Targeted drug delivery
- Photo-responsive
- Polyester
- Click reaction
- Cellular uptake
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