Project Details
Abstract
本計劃將合成製備新穎性犬尿喹酸微胞複合物技術，可以有效改善犬尿喹酸(KA)生物有效率及穿越血腦屏障傳遞進腦部, 除了可增加KA神經保護作用外, 透過強化犬尿氨酸途徑中喹啉酸(QA)/KA的平衡，抑制興奮毒性喹啉酸(QA)產生, 增加抑制NMDA受體，希冀有效地改善神經元細胞神經保護功能, 提高清除多麩醯胺酸鏈聚集體的能力，降低神經元細胞的發炎反應，進而減緩神經退化疾病的病程，並改善腦神經退化小鼠的症狀及壽命。
Project IDs
Project ID:PB11007-4466
External Project ID:MOST109-2221-E182-008-MY3
External Project ID:MOST109-2221-E182-008-MY3
| Status | Finished |
|---|---|
| Effective start/end date | 01/08/21 → 31/07/22 |
Keywords
- micelle nanocomplex
- kynurenic acid
- polyglutamine
- blood-brain barrier
- neurodegenerative diseases
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