Project Details
Abstract
The average age of the Taiwanese population is increasing, and cancer incidence
increases with age. Both improved early detection of first malignancies and effective
primary oncologic therapy have led to prolonged survival, and the risk of second primary
malignancies (SPMs) has consequently increased. The occurrence of SPMs after primary
cancer then becomes an issue of concern to clinicians and patients. Very few reports are
available on the incidence and risk of second primary cancers, and most of these are
single-institution reviews with relatively small case numbers and short follow-up. Our
previous study using the cancer database released from the Taiwan National Cancer
Registry (TNCR) showed 24% increased risk of second cancers in the patients with
nasopharyngeal carcinoma (NPC) compared to the general population in Taiwan
(SIR=1.24, 95% CI=1.15-1.33). The findings of what patients at higher risk for SPM and
what second cancer type most common in specific primary cancer may further improve
clinical management of patients presenting with dual cancers. This is because patients
diagnosedwith multiple, independently derived, primary cancers versus those diagnosed
with a single primary cancer with related metastatic lesions may have a different
prognosis and/or response to therapy and will therefore have different treatment options.
Furthermore, the bivariate failure time model can certainly provide the evaluation of
association between two onset ages and possible risk factors. Specifically, two of the
leading causes of cancer incidence in Taiwan, cervix cancer, column and rectum cancers,
will be focused and denoted as “first primary cancers”in this study. We aim to address
several issues using these population databases provided by Department of Health,
Executive Yuan: (i) find the standardized incidence ratios and cumulative incidence of
second cancers among individuals in whom oral, column or rectum cancers had been
diagnosed as the first malignancy; (ii) establish survival model for those with and
without second cancers; (iii) examine the association distribution for the two correlated
onset ages of cancer; and (iv) establish a bivariate failure time model to address the
effect of covariates.
In summary, we aim to compare the incidence rate and survival probability of SPM
in Taiwan to those in other countries and finally establish a bivariate model for onset
ages of two cancers.
Project IDs
Project ID:PA9712-0639
External Project ID:NSC97-2118-M182-001
External Project ID:NSC97-2118-M182-001
Status | Finished |
---|---|
Effective start/end date | 01/08/08 → 31/07/09 |
Keywords
- second primary malignancy (SPM)
- cumulative incidence
- standardizedincidence ratio
- copula
- bivariate failure time model
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