The Development of Measles Virus-Specific Humoral Immune Response and the Dissection of Its Immune Profiles at the Cellular and Molecular Level in Children (2nd and 3rd Year)( I )

Lin, Tzou-Yien (PI)
Chen, Chih Jung (CoPI)
HUANG, YHU-CHERING (CoPI)
Huang, Kuan Ying (CoPI)

School of Medicine

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

本計畫將促進了解麻疹抗體免疫在細胞與抗體株層次上的組成內容與細節，我們將剖析病毒中和機轉以及抗體在阻斷或干擾麻疹病毒血凝素與宿主細胞受體相互作用中的角色。我們也將分析強效抗病毒血凝素中和抗體與麻疹病毒的結構互動，這將輔助剖析抗體中和病毒的分子機轉。在本計畫，我們也希望，透過整合強效抗病毒血凝素中和抗體的抗原辨識、結構和功能資訊，能促使未來單株抗體免疫療法的臨床前研究與發展。

Project IDs

Project ID:PC11408-3473
External Project ID:NSTC114-2314-B182-064

Status	Active
Effective start/end date	01/08/25 → 31/07/26

Keywords

Measles virus
Human B cell response
Neutralizing antibody
Neutralization mechanism
Receptor blockade

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https://www.grb.gov.tw/search/planDetail?id=18162051

The Development of Measles Virus-Specific Humoral Immune Response and the Dissection of Its Immune Profiles at the Cellular and Molecular Level in Children (2nd and 3rd Year)( I )

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Abstract

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