The Development of Silicon Germanium Light Addressable Potentiometric Sensors for Detecting Hydrogen Peroxide and Free Radical

Nowadays, people care about their life quality and health more and more, and many slight signals such as potassium, urea, pH value, and free radical are some kinds of information of human body. So, it is necessary to build a platform for continuous monitoring these significant signals. In this project, Ge or SiGe will be used as substrate of solid state devices and extended to solid state sensors, such as electrolyte insulator semiconductor (EIS) and light addressable potentiometric sensor (LAPS). LAPS shows high potential on the bio-medical application because of low cost, easy fabrication, and light addressability can be applied to detect chemical image signal. Finally, carbon nano-tube and the cocktail of fibroin and polyanilane with additional enzyme will be fixed on the LAPS sensing membrane to detect H2O2, H2S, free radical and Homocrysteine. This project will be complete in 3 years, including the following parts, 1st Year The development of solid state sensor devices based on Ge or SiGe substrate (1) Device fabrication of MIS and EIS based on Ge or SiGe substrate. (2) Sensing properties for Ge-EIS with the ion concentration for urine and blood. 2nd Year LAPS based on Ge or SiGe substrate and applied on chemical image sensing (1) The development of LAPS based on Ge or SiGe multi-layer substrate. (2) The setup of chemical image sensing. (3) The optimization of spatial resolution. 3rd Year The researches about sensing hydrogen peroxide and free radical by LAPS (1) To fix fibrorin and carbon nano-tube with mixture enzyme on the LAPS device. (2) The sensing platform for H2O2, H2S, homocrysteine and free radical. (3) To transfer the bio-medical signals to chemical image sensing.

Project ID:PB9709-3578
External Project ID:NSC97-2221-E182-054