The Efficacy and Safety of Alirocumab in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis - a Prospective, Randomized, Open-Label, Blinded End-Point Study with Vessel-Wall Mr Imaging (Topical-Mri), the Third Year

Huang, Yen-Chu (PI)
Lee, Meng (CoPI)
Lee, Jiann-Der (CoPI)
Lin, Leng Chieh (CoPI)
Tsai, Yuan Hsiung (CoPI)
Yang, Jen-Tsung (CoPI)

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

顱內動脈硬化狹窄之中風，通常復發率高且易導致永久殘障，目前治療藥物主要是雙重抗血小板和高強度Statin，但高強度Statin通常有較高的副作用，導致治療無法達成。PCSK9的單克隆抗體為一新型藥物，在原本高強度的Statin治療下，仍可有效降低低密度膽固醇，而未增加明顯副作用。本研究是使用高解析度MRI分析ICAS的急性缺血性中風病人，以評估PCSK9單克隆抗體alirocumab的療效和安全性。目前試驗登錄資料中並無相關進行中的研究，如本研究可觀察到正向的結果，未來值得進行phase 3的試驗，探討PCSK9抑制在有症狀顱內動脈硬化狹窄病人中的療效，進而降低再中風風險。

Project IDs

Project ID:PC11209-0200
External Project ID:NSTC112-2314-B182-041

Status	Finished
Effective start/end date	01/08/23 → 31/07/24

Keywords

Intracranial atherosclerotic stenosis (ICAS)
PCSK9
alirocumab
MRI

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The Efficacy and Safety of Alirocumab in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis - a Prospective, Randomized, Open-Label, Blinded End-Point Study with Vessel-Wall Mr Imaging (Topical-Mri), the Third Year

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