Project Details
Abstract
T細胞數量恆定與T細胞活化,對於免疫反應至關重要,報導指出T細胞媒介的自體免疫病患帶有DUSP12基因變異,但仍不知此基因變異的角色.DUSP12去磷酸酶蛋白可調節其受質蛋白的功能與訊號傳遞,但DUSP12在T細胞活化與免疫反應的功能則是完全未知.我們建立T細胞專一性剃除DUSP12小鼠,顯示DUSP12可能參與T細胞數量恆定調節,也可能參與T細胞活化及T細胞所媒介的免疫反應,本計畫將剖析DUSP12在T細胞存活、活化與免疫反應的調節機制,有助於臨床分析DUSP12基因變異的角色與其在發炎或自體免疫疾病之機轉與治療.
Project IDs
Project ID:PC11107-4794
External Project ID:MOST111-2320-B182-025
External Project ID:MOST111-2320-B182-025
| Status | Finished |
|---|---|
| Effective start/end date | 01/08/22 → 31/07/23 |
Keywords
- T cell survival
- T cell activation
- immune response
- DUSP12
- phosphatase
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