The Impact of Aspirin-Triggered Pro-Resolving Pathway on Nasopharyngeal Cancer and Tumor Microenvironment

  • Luo, Sheng-Dean (PI)
  • Lee, Shau-Hsuan (CoPI)
  • Wang, You-Ming (CoPI)
  • Wang, Ching Shuen (CoPI)

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

鼻咽癌的發生與轉移與慢性發炎的腫瘤微環境有明顯的關聯，而無法被解決的慢性發炎反過來又會成為增加鼻咽癌風險的驅動力。最新研究指出，老藥阿斯匹靈的應用不僅是傳統所認知的抑制發炎而已，其也會經腫瘤微環境代謝後產生阿斯匹靈誘導型特異性脂質因子Aspirin triggered Specialized Lipid Mediators，啟動解決癌症發炎(Resolution of Inflammation)的修復機制，讓慢性發炎的腫瘤微環境回復至正常狀態。因此本研究旨在探討經阿斯匹靈治療後，重新啟動解決發炎的分子機制來改善鼻咽癌的治療的重要性，期望在日後能夠提供臨床上治療鼻咽癌一項新的選擇。

Project IDs

Project ID:PC11107-7092
External Project ID:MOST111-2314-B182-068
StatusFinished
Effective start/end date01/08/22 → 31/07/23

Keywords

  • nasopharyngeal carcinoma
  • aspirin
  • aspirin triggered specialized lipid mediators
  • resolution of inflammation
  • cancer resolution
  • tumor microenvironment
  • macrophage polarization
  • cyclooxygenase 2
  • formyl peptide receptor 2
  • autophagy
  • lipidomics.

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