The Impact of Bacteria –Related Inflammatory Reaction on the Process of Liver Regeneration Following Major Liver Resection

  • Chan, Kun-Ming (PI)
  • Lee, Wei-Chen (CoPI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

The liver is a unique organ in the body that has a great ability to regenerate by itself. After loss of considerable liver mass, orchestrated biological responses are quickly activated to restore the loss of liver mass by hepatocyte regeneration until the liver reaches its original size or the body’s physiological requirement. Normally, this regenerative process is mainly based on mature hepatocytes proliferate by the stimulation of the regenerative factors that released from parenchymal and nonparenchymal liver cells. However, bacterial infection encountered in this regeneration process can induce liver injury and massive hepatocyte death leading to compromised liver function and increasing the risk for the development of posthepatectomy liver failure. Specifically, small remnant liver mass is vulnerable after major liver resection, and severe bacterial infection could always result in liver failure and possible mortality. Although numerous cytokines play important roles in the signaling transcription of liver regeneration after liver damage, overexpress of infective cytokines could also cause severe consequence. The key to patient survival must always balance immunological response and basic physiological requirement against remnant liver volume. Therefore, we herein proposed this study to investigate the impact of bacterial infection on the postoperative course of major liver resection in terms of the recovery of liver function, restoration of liver volume, and immunological response related to infective inflammation. An animal model of 70% hepatectomy will be the main subject of this experiment. Then, postoperative administration of Lipopolysaccharide (LPS), a well-known bacterial endotoxin, is setting as a status of bacterial infection. The specific aims of this study are as follow: Specific Aims 1: Characterizing regeneration capacity and liver function recovery of remnant liver in response to the severity of bacterial infection. Specific Aim 2: Characterizing the host immunologic responses against bacterial infection during the liver regeneration period. Specific Aim 3: To identify key factors that induces posthepatectomy jaundice and liver failure in order to prevent morbidity and mortality following major liver resection.

Project IDs

Project ID:PC10207-0828
External Project ID:NSC102-2314-B182-033
StatusFinished
Effective start/end date01/08/1331/07/14

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.