Project Details
Abstract
The liver is a unique organ in the body that has a great ability to regenerate by itself. After
loss of considerable liver mass, orchestrated biological responses are quickly activated to
restore the loss of liver mass by hepatocyte regeneration until the liver reaches its original
size or the body’s physiological requirement. Normally, this regenerative process is mainly
based on mature hepatocytes proliferate by the stimulation of the regenerative factors that
released from parenchymal and nonparenchymal liver cells. However, bacterial infection
encountered in this regeneration process can induce liver injury and massive hepatocyte
death leading to compromised liver function and increasing the risk for the development of
posthepatectomy liver failure. Specifically, small remnant liver mass is vulnerable after
major liver resection, and severe bacterial infection could always result in liver failure and
possible mortality. Although numerous cytokines play important roles in the signaling
transcription of liver regeneration after liver damage, overexpress of infective cytokines
could also cause severe consequence. The key to patient survival must always balance
immunological response and basic physiological requirement against remnant liver volume.
Therefore, we herein proposed this study to investigate the impact of bacterial infection on
the postoperative course of major liver resection in terms of the recovery of liver function,
restoration of liver volume, and immunological response related to infective inflammation.
An animal model of 70% hepatectomy will be the main subject of this experiment. Then,
postoperative administration of Lipopolysaccharide (LPS), a well-known bacterial endotoxin,
is setting as a status of bacterial infection. The specific aims of this study are as follow:
Specific Aims 1: Characterizing regeneration capacity and liver function recovery of
remnant liver in response to the severity of bacterial infection.
Specific Aim 2: Characterizing the host immunologic responses against bacterial infection
during the liver regeneration period.
Specific Aim 3: To identify key factors that induces posthepatectomy jaundice and liver
failure in order to prevent morbidity and mortality following major liver resection.
Project IDs
Project ID:PC10207-0828
External Project ID:NSC102-2314-B182-033
External Project ID:NSC102-2314-B182-033
Status | Finished |
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Effective start/end date | 01/08/13 → 31/07/14 |
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