The participation of CB1 cannabinoid receptor during the development of methamphetamine addiction:significance in mesolimbic dopamine pathway

Project: Ministry of Health and WelfareMinistry of Health and Welfare Commission Research

Project Details


The purpose of this grant proposal is to identify the role of cannabinoid receptor CB1 during the development of methamphetamine (METH) sensitization. We will examine first if CB1 expression altered after chronic methamphetamine treatment, in both protein and mRNA levels. Second, we will treat with CB1 antagonist during either the daily METH injection or at the withdrawal period to delineate the effect of CB1 on METH initiation or behavioral expression stage. In addition, we will examine in vitro in CB1 transfected PC-12 cells the particular signal pathway, such as MAPK, PI3K/Akt/GSK3 signaling. Once the down-steam signal identificed, we will examine in METH-addicted rats if there is similar signal alteration in the nucleus accumbens, the key brain area involve in behavioral sensitization. We believe throught these experiments, we will be able to understand the significance of CB1 receptor on METH addiction.

Project IDs

Project ID:PG9312-0932
External Project ID:DOH94-NNB-1028
Effective start/end date01/01/0531/12/05


  • methamphetamine
  • cannabinoid receptor
  • CB1
  • drug addiction
  • behavioral sensitization
  • nucleus accumbens


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.