Project Details
Abstract
口腔癌是威脅國人健康重大疾病之一,口腔癌病患組織及唾液中表現異常大量的第一型基質金屬蛋白酶 (MMP-1),可作為口腔癌檢測的分子檢驗生物標記,但是有關MMP-1在口腔癌生成或病程進展的過程中的生物功能角色所知甚少。執行本計畫將可深入瞭解MMP-1在口腔癌生成或病程進展的過程中的功能角色與相關分子調控機轉,研發成果預期可促進口腔癌新的生物學發展,同時提供研發新穎口腔癌治療策略的新線索。
Project IDs
Project ID:PC11207-2242
External Project ID:NSTC112-2320-B182-012
External Project ID:NSTC112-2320-B182-012
Status | Finished |
---|---|
Effective start/end date | 01/08/23 → 31/07/24 |
Keywords
- Oral squamous cell carcinoma
- matrix metalloproteinase-1
- mitophage
- quantitative proteomics
- patient-derived xenograft
- adeno-associated virus
- gene silencing
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