The Pathophysiological Role of Matrix Metalloproteinase-1 (Mmp-1) in Oral Cancer

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

口腔癌是威脅國人健康重大疾病之一,口腔癌病患組織及唾液中表現異常大量的第一型基質金屬蛋白酶 (MMP-1),可作為口腔癌檢測的分子檢驗生物標記,但是有關MMP-1在口腔癌生成或病程進展的過程中的生物功能角色所知甚少。執行本計畫將可深入瞭解MMP-1在口腔癌生成或病程進展的過程中的功能角色與相關分子調控機轉,研發成果預期可促進口腔癌新的生物學發展,同時提供研發新穎口腔癌治療策略的新線索。

Project IDs

Project ID:PC11207-2242
External Project ID:NSTC112-2320-B182-012
StatusActive
Effective start/end date01/08/2331/07/24

Keywords

  • Oral squamous cell carcinoma
  • matrix metalloproteinase-1
  • mitophage
  • quantitative proteomics
  • patient-derived xenograft
  • adeno-associated virus
  • gene silencing

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