The Regulatory Mechanism and Therapeutic Potential of Csf1r Pathway in Parkinson'S Disease

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

過去我們發現在的錯誤折疊α-synuclein或其過度表達會增加HMC3微膠細胞中CSF1R的活性。然而，α-synuclein調節CSF1R活性與活化微膠細胞的機制仍然未知。故本計畫旨在探討CSF1R、α-synuclein、TLR和TREM2路徑之間的調控機轉，並釐清CSF1R在調節微膠細胞-神經元相互作用中的角色。進一步測試抑制CSF1R是否可作為治療巴金森氏病的可能策略，我們也將挑選具有CSF1R抑制活性且可穿透血腦屏障的化合物, 於巴金森氏病細胞或動物模型中測試其可能療效。本計畫可能發現新的巴金森氏病神經發炎致病機轉，並提供新的巴金森氏病治療標的。

Project IDs

Project ID:PC11207-1480
External Project ID:NSTC112-2314-B182-040-MY3
StatusFinished
Effective start/end date01/08/23 → 31/07/24

Keywords

  • Parkinson's disease
  • neuroinflammation
  • CSF1R
  • drug discovery
  • induced pluripotent stem cells
  • animal model

Access Project

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
View full fingerprint