The Role of GPR56 in the Modulation of Cell Migration of Human Natural Killer Cells and Melanoma Cells

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


G protein-coupled receptor 56 (GPR56) belongs to the adhesion-type G protein-coupled receptor (adhesion-GPCR) sub-family, which is characterized by a chimeric structure of a very large N-terminal extracellular domain and a seven-pass transmembrane region. Various adhesion-GPCR molecules have been shown to be functionally involved in the immune system, central nervous system and tumorigenesis. GPR56 is closely linked to the onset of bilateral frontoparietal polymocrogyria (BFPP), a rare human brain disorder most likely by inhibiting neural progenitor cell migration. In addition, GPR56 was shown to contribute to the suppression of human melanoma cell metastasis and tumor growth in vivo. More recently, we and others have demonstrated the restricted expression of GPR56 in human natural killer (NK) cells and certain cytotoxic lymphocyte subsets, suggesting a unique function for GPR56 in the immune system. Based upon its novel protein structure and previously identified cellular functions, GPR56 is thought to play a role in regulating cell migration by interacting with specific cellular ligand(s) on neighbouring cells or in the surrounding microenvironment. Hence, we propose to investigate the functional role of GPR56 in modulating the migration of human natural killer cells and melanoma cells.

Project IDs

Project ID:PC10301-0906
External Project ID:NSC101-2320-B182-029-MY3
Effective start/end date01/08/1431/07/15


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