The Role of Sodium-Glucose Co-Transporter-2 (Sglt2) Inhibitors in Suppression of Atrial Fibrillation in Rats with Metabolic Syndrome

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

心房顫動(AF)是一種在臨床上常見的心律不整。代謝症候群病患發生心房顫動風險遠較一般族群機率較高。有限的研究證據顯示第二型鈉-葡萄糖轉運抑制劑似乎可以減少糖尿病患者發生心房顫動機率。本研究將探討SGLT2抑制劑與TRPC3/CaMKII路徑在代謝症候群模型中心房重塑及心房顫動病理機轉所扮演的角色。本研究對於探討代謝症候群病患之心房顫動病理機轉將有重大突破。如能詳細了解探討SGLT2抑制劑是如何抑制TRPC3/CaMKII路徑的方法將在臨床上提供代謝症候群病患諸多心律不整之有效的治療方針。

Project IDs

Project ID:PC11207-0457
External Project ID:MOST110-2314-B182-039-MY3
StatusActive
Effective start/end date01/08/2331/07/24

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.