The Role of Yes-Associated Protein (Yap) and Cyclin-Dependent Kinase 9 (Cdk9) in Regulating Lung Cancer Brain Metastasis and Application of Lung Cancer Patient-Derived Xenograft (Pdx) Mice Model to Develop Novel Treatment (To Continue 2019 Most).( III )

Hsu, Ping-Chih (PI)

School of Medicine

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

藉由腦轉移腫瘤細胞株的建立，我們可在未來同樣小鼠模型進行更多轉移機轉研究及尋找合適的治療藥物。病人源性腫瘤細胞異種移殖技術之引進，能正確地保留腫瘤的分子多樣性、分化程度、細胞異質性、腫瘤微環境和組織特徵等；其血管與間質特徵，以及壞死狀態也與人體本身的腫瘤特性更為相近。本研究在建立穩定的肺癌腦轉移小鼠模型和病人源性腫瘤細胞異種移殖小鼠模型後，這不只在本計畫的研究，將來這些模型也可以提供個實驗室在做精準醫療時，藥物的發展以及篩選，讓肺癌的治療研究上有一個良好的工具，對於腫瘤生物學的進展及癌症新藥的研發扮演重要的角色，相信對於腫瘤治療會有一大進步。

Project IDs

Project ID:PC11107-4539
External Project ID:MOST111-2628-B182-011

Status	Finished
Effective start/end date	01/08/22 → 31/07/23

Keywords

Lung cancer
brain metastasis
Yes-associated protein
Hippo pathway
lung cancer brain metastatic murine model
lung cancer patient-derived xenografts (PDX) models Cyclin-dependent kinase 9 (CDK9)

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https://www.grb.gov.tw/search/planDetail?id=14499979

The Role of Yes-Associated Protein (Yap) and Cyclin-Dependent Kinase 9 (Cdk9) in Regulating Lung Cancer Brain Metastasis and Application of Lung Cancer Patient-Derived Xenograft (Pdx) Mice Model to Develop Novel Treatment (To Continue 2019 Most).( III )

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