The Roles of Dna Damage Response Pathways in Post-Irradiation Cancer Immune Evasion

Hsieh, Rodney Cheng-En (PI)
Chan, Kun-Ming (CoPI)
Chen, Fang-Hsin (CoPI)
Chen, Miao-fen (CoPI)
Chen, Chun Bing (CoPI)
Cheng, Ching Chung (CoPI)
Chern, Yih Jong (CoPI)
Chou, Yung Chih (CoPI)
Hsu, Cheng-Lung (CoPI)
Hsu, Hung Chih (CoPI)
Huang, Pei Wei (CoPI)
Hung, Shuen-lu (CoPI)
Ko, Chun Jung (CoPI)
Lee, Chao Wei (CoPI)
Lee, Jin Chiao (CoPI)
Tsai, Wen Sy (CoPI)
Tsai, Tsung You (CoPI)
Wang, Chun-Chieh (CoPI)
Wang, Fang Ying (CoPI)
Wu, Ren-Chin (CoPI)
Wu, Chiao-En (CoPI)
Wu, Ting (CoPI)
You, Jeng Fu (CoPI)
Yu, Ching-Fang (CoPI)

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

放療是現今癌症治療的主要方式之一，約一半癌症患者在其療程中會接受某種形式的放療。局部放療可促進免疫系統活化以攻擊遠端未受照射的腫瘤，但癌細胞可運用免疫逃脫機制抑制宿主免疫活化，導致放療之全身性療效目前仍不理想，而其中分子機轉目前尚不明朗。本團隊過去研究發現癌細胞可利用DNA損害反應來抑制放療後免疫系統活化，本計畫欲全面性探討此DNA損害反應路徑中各節點對癌細胞免疫逃脫的重要性，利用組織銀行檢體、患者源性異種移植腫瘤及同源移植小鼠模型分析腫瘤微環境變化，並尋找此路徑中能增強放療後免疫反應效用最佳之藥物，以提升癌症免疫治療療效，完成此計畫可為未來臨床試驗設計提供重要理論依據。

Project IDs

Project ID:PC11210-0007
External Project ID:NSTC111-2314-B182-071-MY2

Status	Finished
Effective start/end date	01/11/23 → 31/10/24

Keywords

radiotherapy
cancer immune escape
DNA damage response
phagocytosis checkpoint
cGAS-STING
tumor microenvironment
abscopal effect
next generation sequencing

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https://www.grb.gov.tw/search/planDetail?id=15639662

The Roles of Dna Damage Response Pathways in Post-Irradiation Cancer Immune Evasion

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Abstract

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