Project Details
Abstract
Patient safety and medical quality are top issues for both clinical practitioners and
administrators in the current health care systems world wide. One of the major concerns in
patient safety or medical quality is the safety related to drug medications, such as adverse
drug reactions (ADR). There are over 106,000 inpatients expired due to Adverse Drug
Reactions every year in the United States, which severely damage both to patient’s health and
health care systems. Under the supports from department of health in Taiwan, the association
of pharmacists had constructed a nation wide reporting system for ADR in 1998. Chang Gung
Memorial Hospital (CGMH) began to build up the similar reporting system for ADR in 2002,
and the system became established and reliable with the appropriate deployments of related
human resources in 2004.
The analyses of such ADR data were primarily based on descriptive statistics, which was
far from the purposes of high risk group prediction and active intervention planning. A large
number of documents had emphasized the importance of identifying risk factors related to
ADR, while there were significant implications for both health care administration and
academic values. Therefore, this study will utilize data base from reporting system and other
sources of medical records to explore factors related to the occurrence of ADR, the
subsequent prognoses, and additional medical consumptions from ADR. With the information,
the healthcare providers may conduct a more safe practice and interventions for reducing
harms from ADR in the future.
A serial of case-control study nested in a large cohort of CGMH patient file during
2005-2011 will be performed for ADR studies. The severity of ADR will be evaluated with
Naranjo algorithms by senior pharmacists in the medical center. The variables to be collected
as major risk factors for ADR are age, sec, BMI, life-style variables,
comorbidities/complications, drug type, and physician’s professional background. Additional
length of stay and medical expenditures are two primary indicators for medical consumptions
in this study. Various regression models will be applied to analyze data under diverse
conditions. The objectives of this study are as follows.
1. Test the association between hypothesized risk factors and the occurrence or severity of
ADR.
2. Identify the characteristics of high risk group in developing ADR or becoming severe ADR
cases.
3. Explore the additional medical consumptions caused by the occurrence of ADR.
4. Further understand the disease prognoses affected by the occurrence of ADR.
It is synchronized responsibility of all health care providers including physicians,
nurses, pharmacists, and administrators to do whatever efforts in preventing the occurrence
and harms from ADR. The anticipated findings from this study will help to design an
effective system for preventing ADR in health care management. From the identification of
high risk group, this study offers clues for interventions and future pharmaco-genomic
studies. The battle on reducing ADR will receive more attentions and achievements from the
study so that patient safety and quality of care will be gradually more secured under
reasonable cost in the future.
Project IDs
Project ID:PF10001-0715
External Project ID:NSC98-2410-H182-011-MY3
External Project ID:NSC98-2410-H182-011-MY3
Status | Finished |
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Effective start/end date | 01/08/11 → 31/07/12 |
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