The Study on Optical Coherence Angiography and Its Application

In this proposal, Optical Coherence Angiography system will be developed to observe the vascular dysplasia in tumor tissue. Optical Coherence Tomography can reconstruct the tissue structure about 2-3 mm in depth. With Doppler Effect, the blood velocity can be measured with optical coherence tomography system. However, this technique is limited by the several parameters such as the angle between the incident beam and the vascular, and the phase noise. Therefore, it is hard to reconstruct in vivo three-dimensional image of vascular. In this proposal, we modify the setup of OCT system by utilizing a PZT transducer to reconstruct the vascular image without the information about the angle between the incident beam and the vascular. In addition, a reference signal in the sample arm is used as a calibration signal to reduce the phase noise. Also, an algorithm will be developed to calibrate the phase noise and calculate the phase shift induced by the movement of the blood cells. OCA system not only can provide the 3D structural image of biological tissue but also can reconstruct the 3D vascular image which will contain the arteries, veins and capillaries. At last, we hope to apply OCA system for the study of vascular dysplasia to observe the angiogenesis in the evolution of tumor. It will be useful to be an early diagnosis tool in the early stage of cancer in the future.

Project ID:PB9907-12660
External Project ID:NSC99-2221-E182-044