Project Details
Abstract
Diabetes mellitus (DM) has become one of the main threats to human health in the 21st
century. It is projected that by the year 2010, about 220 million people will be inflicted. Our
understanding of the DM is largely on the detrimental effects of hyperglycemia and
hyperlipidemia, including its pathophysiological effects on cardiovascular, renal and nervous
systems. In recent years, research on the pathogenesis of DM and its complications have been
focussed on AGE-RAGE elicited signals and their effects, increased fatty acid levels and
insulin resistance, adipocytes and adipokines, increased ROS and inflammation in a systemic
nature etc.. Thus, a systemic, in vivo approach to study the DM-inflicted metabolic disorders
appeared to be appropriate. Here, we propose a relatively more holistic approach, the
metabonomics, to detect, quantify, and catalogue the time related metabolic processes of the
DM rats (with reference to the age-matched normal rats), and to relate such processes to the
trajectories of the pathophysiological events occurring in DM , and to explore the action
mechanisms underlying the metabolic benefits of resveratrol (a compound that has been
shown to have metabolic benefits in mice on high fat diet, and in streptozotocin-induced DM
rats). In recenty years, systemic oxidative stress and inflammation have been believed to
implicate in DM pathology. Here are propose that the burdens of oxidative
stress/inflammation could be varied among tissues/organs resulting in varied organ/tissue
pathological complications in DM animals/subjects. In this proposal , we will also quantitate
and track the changes of some selected biomarks for oxidative strss and in lammation in
plasma and tissues/organs (including brain, liver, kidneys, heart, skeletal muscles and fat
tissues etc.) of the normal and Dm rats with and without RSV treatment.
We have performed some preliminary studies to analyse the urine metabolites of the
normal, DM, and resveratrol-treated DM rats. Through the “condition tree” analysis, we have
been able to see prominent differences among the urine metabolite complements of the 3
groups of rats. (part of our results have been published in American J. physiology, please see
the Preliminary Results). Through our study, we should be able to gain better understanding
of the pathophysiology of the DM rats and the health benefits of the resveratrol in the areas of
energy metabolism.
Project IDs
Project ID:PC10208-0582
External Project ID:NSC102-2320-B182-033
External Project ID:NSC102-2320-B182-033
Status | Finished |
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Effective start/end date | 01/08/13 → 31/07/14 |
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