To Identify the Correlation between Non-Invasive Swallowing-Respiration Assessment and Vi Deo-Fluorography Swallowing Study in Normal Controls and Post-Stroke Dysphagic Patients

Background: Neurogenic oropharyngeal dysphagia is an important issue in rehabilitation. Video-fluoroscopy swallowing study (VFSS) is a gold standard swallowing test with disadvantage of radiation exposure. However, more objective and non-invasive instruments have been introduced to measure the oropharyngeal swallowing. In our laboratory, non-invasive swallowing and respiration assessment tools are under developing, and related researches are undergoing. A new miniature pressure sensor (MPS) instead of Piezo-electrical sensor and FSR has been used which also showed sensitive enough to detect laryngeal excursion during swallowing in our laboratory using Biopac system. Besides, the laryngeal excursion waveforms recorded using MPS are similar to those recorded using the bend sensor and FSR. So far, new MPS detecting the laryngeal excursion in noninvasive swallowing and respiration assessment using Biopac system in our laboratory is not yet correlated with VFSS neither in normal controls nor in post-stroke dysphagic patients. In post-stroke dysphagia, this non-invasive swallowing assessment was not yet correlated to the penetration and aspiration scale in VFSS either. Aims: 1. To identify the correlation between the swallowing signals of laryngeal excursion by MPS and VFSS in normal controls; 2. To identify the correlation of parameters and events of oropharyngeal swallowing detected by non-invasive system and VFSS in post-stroke dysphagia; 3. To identify the oropharyngeal and respiratory parameters of non-invasive assessment with a significant correlation to predict the penetration and aspiration scale of VFSS in post-stroke dysphagia. In the first study year, VFSS and MPS, VFSS images during liquid Barium swallowing will be recorded in 25 male and 25 female normal volunteers (age ranged 20-40 years old). In each subject, measurements of swallowing by synchronized VFSS and MPS (non-invasive swallowing and respiration assessment using Biopac system) will be performed. Images and signals of four separated single swallow of 5 ml barium liquid (30% wt/volume%) will be recorded. During study, subjects will be asked to sit on a chair with their head vertical to the Frankfort plane. The radiation exposure time will be controlled under 2 minutes, and total test period will take less than 20 minutes. In the 2nd study year, the 40 post-stroke dysphagic patients, aged 25-75 years old, who will be had VFSS arranged routinely and clinically. A non-invasive swallowing and respiration coordination study will be arranged within 24 hours of the regularly scheduled VFSS. The parameters of swallowing signals by non-invasive assessment will be tested of the correlation to the motion parameters and to the “penetration and aspiration scale” by VFSS examination.

Project ID:PC10607-0351
External Project ID:MOST106-2314-B182-021