To Study Sox4-Stat6 Complex in Modulating Proliferation, Metabolism in Hepatocellular Carcinoma Cells and Clinical Impact on Drug Resistance in Patients

Tsai, Chi-Neu (PI)
Yu, Ming Chin (CoPI)

Graduate Institute of Clinical Medical Sciences

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

肝細胞癌（HCC）的治療中腫瘤栓塞、免疫治療以及酪胺酸激酶抑制劑（TKIs）等治療進展已改善晚期HCC的疾病控制，仍有許多患者面臨疾病惡化的問題。在此計畫中我們將探討SOX4-STAT6及其下游的訊息傳導路徑對於細胞代謝, 生長及抗藥性的關聯性. 希望能對肝細胞癌的治療有所助益.

Project IDs

Project ID:PC11407-5361
External Project ID:NSTC114-2320-B182-014

Status	Active
Effective start/end date	01/08/25 → 31/07/26

Keywords

Hepatocellular carcinoma
SOX4
STAT6
cellular metabolism
drug resistance

Access Project

https://www.grb.gov.tw/search/planDetail?id=18010176