To Study the Role of Polysaccharide Intercellular Adhesion on the Regulation of Agr Quorum Sensing System in Staphylococcus Aureus

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

金黃葡萄球菌為造成院內感染的主要病原菌之一，其具形成生物膜的能力，使治療更為棘手。生物膜的成熟是藉由多醣類黏菌素 (PIA)，構成生物膜的基質。我們研究顯示PIA可能經Agr群聚感應系統而具有調控其它致病因子的功能，或是對宿主有致病性及影響免疫反應。藉由我們的研究，可以對金黃葡萄球菌的致病機轉有更多的瞭解及臨床應用，PIA也可做為抗菌製劑的標地，成為對抗多重抗藥性菌株的策略。

Project IDs

Project ID:PC11008-0339
External Project ID:MOST108-2320-B182-031-MY3
StatusFinished
Effective start/end date01/08/21 → 31/07/22

Keywords

  • Staphylococcus aureus
  • polysaccharide intercellular adhesin (PIA)
  • Agr
  • pathogenesis

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