Project Details
Abstract
Multifunctional magnetic nanoparticles can be synthesized by modifying the DNA targeting ligands on the
nanoparticle surface via cross-linking agent. This project aims to develop the platform of transient expression
system by combining the magnetic nanoparticles and adult mesenchymal stem cells for the production of
autologous antibody. This transient expression technology is for the patient's tailed manufacture by using his
own cells to produce important growth factors and antibodies. We plan to use the human mesenchymal stem
cells as a antibodies host. The serum-free media for plasmid transfection and protein expression will be
developed in the first stage. The performance of cationic nanoparticles in transfection efficiency and protein
yield will be evaluated. The relationship between the structure of cationic ligand and the transfection
efficiency will be discussed in this project.
Project IDs
Project ID:PB10407-0145
External Project ID:MOST104-2221-E182-059
External Project ID:MOST104-2221-E182-059
Status | Finished |
---|---|
Effective start/end date | 01/08/15 → 31/07/16 |
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.