Unraveling the Mechanism of Planar Polarity Establishment Using Corneal Endothelial Monolayer as a Model ~ Lineage-Tracing Lgr5+ Cells' Fate Conversion and the 3d Corneal Endothelial Organoid Formation in Transgenic Mice

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details

Abstract

本研究將培育基因轉殖小鼠,進行譜系追踪並觀察發育或損傷時,平面極性建立及修護的動態過程。我們將分離和擴增角膜內皮細胞中各種狀態細胞,並分析其基因表現。本計畫旨在探究角膜內皮層組織形成過程,明瞭其潛在機制將有助於開發安全、有效的角膜內皮重建技術。

Project IDs

Project ID:PC11307-1767
External Project ID:NSTC113-2314-B182-015-MY3
StatusActive
Effective start/end date01/08/2431/07/25

Keywords

  • corneal endothelial cell (CEC)
  • planar cell polarity (PCP)
  • Lgr5 transgenic mice
  • cornea endothelial progenitor-like cells (HCEPLCs)
  • tissue patterning
  • organoid.

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