Unraveling the Network Mechanisms in Cortical Dysplasia-Associated Epilepsy: a Comprehensive Study on Cortical Brain States and Corticothalamic Microcircuits

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Project Details

Abstract

大腦「起」與「落」狀態目前局限於神經科學的研究。我們將「起」與「落」狀態的觀念引入至癲癇的研究，並且在嬰兒痙攣動物模型上發現其在癲癇產生上扮演重要角色。由於我們證明嬰兒痙攣屬於皮質癲癇，如果我們在另一種臨床常見的頑固型皮質癲癇—皮質發育不全相關癲癇—的動物模型上發現相同之關係，並藉由人工智慧機器學習證實這是預測癲癇產生的重要特徵，這將證實大腦「起」與「落」狀態可能是皮質癲癇的共同網路致病機轉，而皮質癲癇藉由過度活化「起」與「落」生理現象來產生癲癇病灶。此發現將有助發展傳統藥物外的癲癇精準醫療—針對大腦網路導致癲癇的致病機轉做高科技神經調控治療。

Project IDs

Project ID:PC11307-2942
External Project ID:NSTC113-2314-B182-068
StatusActive
Effective start/end date01/08/24 → 31/07/25

Keywords

  • cortical dysplasia
  • up and down states
  • PTEN knockout
  • corticothalamic microcircuit
  • DREADD

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