Using Lung Cancer Patient-Derived Xenograft (Pdx) to Explore the Interaction between Yap Signaling Pathway and Cyclin-Dependent Kinases (Cdk) and New Therapeutic Target for Lung Cancer

Hsu, Ping-Chih (PI)

School of Medicine

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

在我們先前的計劃中，我們已經成功建立9株的肺癌病患源生異種移植小鼠模型(PDX)，並且穩定培養到第三代以上，在幾株的PDX基因定序中發現有相關於調控細胞週期素激酶和細胞週期的基因活化變異，我們終期是利用小鼠腫瘤模型和PDX去測試找出能有控制晚期肺癌的YAP/CDKs 抑制藥物。這樣的利用PDX模型做的藥物治療測試較能符合實際臨床人體的反應和環境，數據可以提供給肺癌治療發展上的參考，甚至可以找出其他現有抗癌藥物中適合某些群體病人的藥物治療。這些PDX模型除了我們計畫使用外，其實也可以提供給其他在發展肺癌藥物研究單位一個合作的平台和工具。

Project IDs

Project ID:PC11207-0385
External Project ID:NSTC112-2314-B182-067

Status	Finished
Effective start/end date	01/08/23 → 31/07/24

Keywords

Lung cancer
metastasis
Yes-associated protein
Hippo pathway
lung cancer drug resistance
lung cancer patient-derived xenografts (PDX) models
Cyclin-dependent kinases (CDKs) and cell cycle

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https://www.grb.gov.tw/search/planDetail?id=15423890

Using Lung Cancer Patient-Derived Xenograft (Pdx) to Explore the Interaction between Yap Signaling Pathway and Cyclin-Dependent Kinases (Cdk) and New Therapeutic Target for Lung Cancer

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