Utilization of Micro 3-D Cell Culture and Optical Microfluidic System for Circulating Tumor Cell Isolation and Chemosensitivity Assays Respectively-Exploring Their Cancer Metastasis Relevance and Feasibility Using the Assay for Guiding Cancer Chemotherapy

Wu, Min-Hsien (PI)
Hsieh, Chia Hsun (CoPI)

Department of Biomedical Engineering

Project: National Science and Technology Council › National Science and Technology Council Academic Grants

Abstract

循環腫瘤細胞是存在於癌症病患血液中的稀有細胞，這些細胞被認為與癌轉移有關。從血液中純化分離出的循環腫瘤細胞，可以被當成一種液態腫瘤檢體，它可用於抗癌藥物藥敏性測試，進而篩選有效的個人癌症藥物治療方。為此，本計劃提出一項能夠純化分離高純度、無標示、存活、且在生理上與癌症轉移具有關連性的循環腫瘤細胞，上述特性係目前其它循環腫瘤細胞純化分離方法所無法實現的。這些特殊的細胞除了可以應用於癌症基礎研究外，本研究擬展示利用上述特殊循環腫瘤細胞，來進行抗癌藥物藥敏性測試，最後將驗證利用前述測試結果來指導個人化癌症藥物治療的可行性。整體而言，我們深切期待本研究計畫的成果，能為癌症精準醫療的願景作出貢獻。

Project IDs

Project ID:PB11207-0912
External Project ID:MOST110-2221-E182-004-MY3

Status	Finished
Effective start/end date	01/08/23 → 31/07/24

Keywords

Circulating Tumor Cells
Microfluidic Cell Culture
Chemosensitivity Assay
Cell Isolation and Purification

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https://www.grb.gov.tw/search/planDetail?id=15426997

Utilization of Micro 3-D Cell Culture and Optical Microfluidic System for Circulating Tumor Cell Isolation and Chemosensitivity Assays Respectively-Exploring Their Cancer Metastasis Relevance and Feasibility Using the Assay for Guiding Cancer Chemotherapy

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