WD40-Repeat Protein Family and Gout

  • Chen, Chung-Jen (PI)

Project: National Science and Technology CouncilNational Science and Technology Council Academic Grants

Project Details


From our epigenetic study on gout, we have identified one member of WD40-repeat (WDR) protein family, known as WDR52, might be related with development of gout. Besides WDR52, other WDR molecules are also related with gout from our preliminary study. In the three years of project, we will study systemically the role of WDR family on gout in the first year to validate key WDR molecules associated with gout. Then, we will investigate their molecular mechanism contributing to the development of hyperuricemia, gout, or tophi. Finally, we will develop new strategies to modulate the key WDR molecules in patients with gout. In total, 50 adult men with normouricemia (normal control group), 50 adult men with asymptomatic hyperuricemia, 50 adult men with non-tophaceous gout and 50 adult men with chronic topaceous gout will be enrolled. We expect that this project will be a new milestone for gout, one of the most ancient and most common diseases in the world.

Project IDs

Project ID:PC10308-0989
External Project ID:MOST103-2314-B037-076
Effective start/end date01/08/1431/07/15


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