μ opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethality

Horace H. Loh; Hsien Ching Liu; Antonella Cavalli; Wanling Yang; Yuh Fung Chen; Li Na Wei

doi:10.1016/S0169-328X(97)00353-7

μ opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethality

Horace H. Loh^*
, Hsien Ching Liu
, Antonella Cavalli
, Wanling Yang
, Yuh Fung Chen
, Li Na Wei

^*Corresponding author for this work

University of Minnesota Twin Cities

Research output: Contribution to journal › Journal Article › peer-review

305 Scopus citations

Abstract

The μ opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of μ-specific opioid ligands and acute morphine lethality are mediated by the μ receptor.

Original language	English
Pages (from-to)	321-326
Number of pages	6
Journal	Molecular Brain Research
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/S0169-328X(97)00353-7
State	Published - 01 03 1998
Externally published	Yes

Keywords

Gene-targeting
Morphine analgesia
Morphine lethality
μ opioid receptor

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10.1016/S0169-328X(97)00353-7

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title = "μ opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethality",

abstract = "The μ opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of μ-specific opioid ligands and acute morphine lethality are mediated by the μ receptor.",

keywords = "Gene-targeting, Morphine analgesia, Morphine lethality, μ opioid receptor",

author = "Loh, \{Horace H.\} and Liu, \{Hsien Ching\} and Antonella Cavalli and Wanling Yang and Chen, \{Yuh Fung\} and Wei, \{Li Na\}",

year = "1998",

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T2 - Effects on ligand-induced analgesia and morphine lethality

AU - Loh, Horace H.

AU - Liu, Hsien Ching

AU - Cavalli, Antonella

AU - Yang, Wanling

AU - Chen, Yuh Fung

AU - Wei, Li Na

PY - 1998/3/1

Y1 - 1998/3/1

N2 - The μ opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of μ-specific opioid ligands and acute morphine lethality are mediated by the μ receptor.

AB - The μ opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of μ-specific opioid ligands and acute morphine lethality are mediated by the μ receptor.

KW - Gene-targeting

KW - Morphine analgesia

KW - Morphine lethality

KW - μ opioid receptor

UR - https://www.scopus.com/pages/publications/0032031040

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SP - 321

EP - 326

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 2

ER -

μ opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethality

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Keywords

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