專一性抑制葡萄糖調節蛋白-78(Grp78)表現之RNA干擾(RNAi)序列、抑制藥劑及抑制方法

Joseph Tung-Chieh Chang; Ching-Chi Chiu; Ann-Joy Cheng

專一性抑制葡萄糖調節蛋白-78(Grp78)表現之RNA干擾(RNAi)序列、抑制藥劑及抑制方法

Translated title of the contribution: RNAi sequence, inhibitor, and inhibition method that specifically inhibits expression of 78-kDA glucose-regulated protein

Joseph Tung-Chieh Chang (Inventor), Ching-Chi Chiu (Inventor), Ann-Joy Cheng (Inventor)

Research output: Patent

Abstract

Disclosed are an RNAi sequence, an inhibitor, and an inhibition method that specifically inhibits expression of 78-kDA glucose-regulated protein, in which a segment of RNA interference sequence: 5'-AAGGATGGTTAATGATGCTGAGAA-3', that induces complementation with 78-kDA glucose-regulated protein is designed. The sequence forms a special hair-pin structure inside a cancer cell to realize specific and effective inhibition of the function of expression of 78-kDA glucose-regulated protein thereby inhibiting oncogenesis of cancer cell, including cell growth and invasive migration.

Translated title of the contribution	RNAi sequence, inhibitor, and inhibition method that specifically inhibits expression of 78-kDA glucose-regulated protein
Original language	Chinese (Traditional)
IPC	A61K 38/16(2006.01); A61P 35/00(2006.01); C12N 15/11(2006.01)
State	Published - 16 07 2009

Bibliographical note

公開公告號: 2.00930398E8
Announcement ID: 2.00930398E8

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@misc{b2d72c39629b465eb1f8e5f31dd68b19,

title = "專一性抑制葡萄糖調節蛋白-78(Grp78)表現之RNA干擾(RNAi)序列、抑制藥劑及抑制方法",

abstract = "一種專一性抑制葡萄糖調節蛋白-78表現之RNA干擾序列、抑制藥劑及抑制方法，係藉由設計一段可與葡萄糖調節蛋白-78分子產生互補作用的RNA干擾序列:5'-AAGGATGGTTAATGATGCTGAGAA-3'，此序列會在癌細胞內形成特殊的髮夾結構，達到專一性並有效地抑制葡萄糖調節蛋白-78表現的功能，進而抑制癌細胞之癌化過程，包含細胞生長和侵犯轉移。",

author = "Chang, {Joseph Tung-Chieh} and Ching-Chi Chiu and Ann-Joy Cheng",

note = "A61K 38/16(2006.01); A61P 35/00(2006.01); C12N 15/11(2006.01)",

year = "2009",

month = jul,

day = "16",

language = "繁體中文",

type = "Patent",

}

TY - PAT

T1 - 專一性抑制葡萄糖調節蛋白-78(Grp78)表現之RNA干擾(RNAi)序列、抑制藥劑及抑制方法

AU - Chang, Joseph Tung-Chieh

AU - Chiu, Ching-Chi

AU - Cheng, Ann-Joy

N1 - 公開公告號: 2.00930398E8 Announcement ID: 2.00930398E8

PY - 2009/7/16

Y1 - 2009/7/16

N2 - 一種專一性抑制葡萄糖調節蛋白-78表現之RNA干擾序列、抑制藥劑及抑制方法，係藉由設計一段可與葡萄糖調節蛋白-78分子產生互補作用的RNA干擾序列:5'-AAGGATGGTTAATGATGCTGAGAA-3'，此序列會在癌細胞內形成特殊的髮夾結構，達到專一性並有效地抑制葡萄糖調節蛋白-78表現的功能，進而抑制癌細胞之癌化過程，包含細胞生長和侵犯轉移。

AB - 一種專一性抑制葡萄糖調節蛋白-78表現之RNA干擾序列、抑制藥劑及抑制方法，係藉由設計一段可與葡萄糖調節蛋白-78分子產生互補作用的RNA干擾序列:5'-AAGGATGGTTAATGATGCTGAGAA-3'，此序列會在癌細胞內形成特殊的髮夾結構，達到專一性並有效地抑制葡萄糖調節蛋白-78表現的功能，進而抑制癌細胞之癌化過程，包含細胞生長和侵犯轉移。

M3 - 專利

ER -

專一性抑制葡萄糖調節蛋白-78(Grp78)表現之RNA干擾(RNAi)序列、抑制藥劑及抑制方法

Abstract

Bibliographical note

UN SDGs

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Cite this