早發型帕金森病(D331Y)PLA2G6突變基因嵌入模式與藥物篩選平台和方法

Translated title of the contribution: EARLY-ONSET PARKINSON'S DISEASE MODEL: (D331Y) PLA2G6 KNOCKIN MODEL, AND PLATEFORM AND METHOD FOR DRUG SCREENING

Ching-Chi Chiu (Inventor), Hung-Li Wang (Inventor), TU-HSUEH YEH (Inventor)

Research output: Patent

Abstract

Disclosed is a (D331Y) PLA2G6 knockin mouse, which shows similar clinical symptoms to those of patients suffering from Parkinson’s disease (PD), and begins to display early-onset cell death of dopaminergic neurons in its substantia nigra (SN), synucleinopathy, and tau pathology at the age of about 6 months, wherein the dopaminergic neurons exhibit mitochondrial structural abnormality and dysfunction. Treatment of the (D331Y) PLA2G6 knockin mouse with L-Dopa shows a good response. The (D331Y) PLA2G6 knockin mouse can be used as a platform for developing a medicament and method for treating PD.
Translated title of the contributionEARLY-ONSET PARKINSON'S DISEASE MODEL: (D331Y) PLA2G6 KNOCKIN MODEL, AND PLATEFORM AND METHOD FOR DRUG SCREENING
Original languageChinese (Traditional)
Patent numberI695891
IPCC12Q 1/6876(2018.01); C40B 30/00(2006.01)
StatePublished - 11 06 2020

Bibliographical note

公開公告號: I695891
Announcement ID: I695891

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