Abstract
The invention provides small interfering RNA (siRNA) and their carriers that could treat asthma in mammalian through inhibiting acidic mammalian chitinase (AMCase) gene expression. The invention further provides a composition comprising siRNA of the present invention and a carrier. The invention also provides a method for treating asthma of a subject.
Translated title of the contribution | DEVELOPMENT OF ASTHMA THERAPY WITH rAAV-mediated AMCase shRNA |
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Original language | Chinese (Traditional) |
Patent number | I378800 |
IPC | A61K 48/00(2006.01); C12N 15/63(2006.01); C12N 15/861(2006.01); A61P 11/06(2006.01) |
State | Published - 11 12 2012 |
Bibliographical note
公開公告號: I378800Announcement ID: I378800