FPR1拮抗劑的衍生物及其用途(二)

Translated title of the contribution: FPR1 ANTAGONIST DERIVATIVES AND USE THEREOF (2)

Pei-Wen Hsieh (Inventor), Tsong-Long Hwang (Inventor), YIN-TING HUANG (Inventor), CHIH-HAO HUNG (Inventor)

Research output: Patent

Abstract

Binding of fomyl peptide receptor 1 (FPR1) byN-formyl peptides can induce neutrophil activation and may represent a new therapeutic target in either sterile or septic inflammation. In present application, a series of new dipeptide derivatives as shown general formula (I) is provided. Of these, each of R1 and R4 is one selected from a group consisting of hydrogen atom, hydroxyl group, C1-C4alkyl, C1-C4alkoxyl and glycin-nitrile amide group; each of R2 and R3 is one selected from a group consisting of hydrogen atom, hydroxyl group, pyridinyl group, phenyl group, pyridinyl group, C1-C4alkoxyl substitute on the ester group, and a hydroxyl group, halogen group, C1-C4alkoxyl group, C1-C4alkyl group substitute on the aromatic ring of benzoyl group. Additionally, the configurations of two amino acids areSandRconfigurations, respectively.
Translated title of the contributionFPR1 ANTAGONIST DERIVATIVES AND USE THEREOF (2)
Original languageChinese (Traditional)
IPCA61K 31/405(2006.01); A61K 38/05(2006.01); C07D 209/20(2006.01); C07K 5/078(2006.01)
StatePublished - 16 09 2015

Bibliographical note

公開公告號: 2.01534298E8
Announcement ID: 2.01534298E8

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