Abstract
Binding of fomyl peptide receptor 1 (FPR1) byN-formyl peptides can induce neutrophil activation and may represent a new therapeutic target in either sterile or septic inflammation. In present application, a series of new dipeptide derivatives as shown general formula (I) is provided. Of these, each of R1 and R4 is one selected from a group consisting of hydrogen atom, hydroxyl group, C1-C4alkyl, C1-C4alkoxyl and glycin-nitrile amide group; each of R2 and R3 is one selected from a group consisting of hydrogen atom, hydroxyl group, pyridinyl group, phenyl group, pyridinyl group, C1-C4alkoxyl substitute on the ester group, and a hydroxyl group, halogen group, C1-C4alkoxyl group, C1-C4alkyl group substitute on the aromatic ring of benzoyl group. Additionally, the configurations of two amino acids areSandRconfigurations, respectively.
Translated title of the contribution | FPR1 ANTAGONIST DERIVATIVES AND USE THEREOF (2) |
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Original language | Chinese (Traditional) |
IPC | A61K 31/405(2006.01); A61K 38/05(2006.01); C07D 209/20(2006.01); C07K 5/078(2006.01) |
State | Published - 16 09 2015 |
Bibliographical note
公開公告號: 2.01534298E8Announcement ID: 2.01534298E8