ＦＰＲ１拮抗劑的衍生物及其用途

Binding of fomyl peptide receptor 1 (FPR1) byN-formyl peptides can induce neutrophil activation and may represent a new therapeutic target in either sterile or septic inflammation. In present application, a series of new dipeptide derivatives as shown general formula (I) is provided. Of these, each of RK and RT is one selected from a group consisting of hydrogen atom, hydroxyl group, C1-C4alkyl, C1-C4alkoxyl and glycin-nitrile amide group; each of RM and RS is one selected from a group consisting of hydrogen atom, hydroxyl group, pyridinyl group, phenyl group, pyridinyl group, C1-C4alkoxyl substitute on the ester group, and a hydroxyl group, halogen group, C1-C4alkoxyl group, C1-C4alkyl group substitute on the aromatic ring of benzoyl group. Additionally, the configurations of two amino acids areSandRconfigurations, respectively.