17,20-Epoxysteroids from octocoral Isis hippuris (Linnaeus, 1758)

Yi Qi Huang; Po Jen Chen; San Nan Yang; Su Ying Chien; Li Guo Zheng; Zhi Hong Wen; Liang Mou Kuo; Ping Jyun Sung

doi:10.1016/j.tetlet.2022.154142

17,20-Epoxysteroids from octocoral Isis hippuris (Linnaeus, 1758)

Yi Qi Huang, Po Jen Chen, San Nan Yang, Su Ying Chien, Li Guo Zheng, Zhi Hong Wen, Liang Mou Kuo^*, Ping Jyun Sung

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

Three 17,20-epoxysteroids, including a new metabolite, hippuristeroketal B (1), as well as two known compounds, hippuristerones A (2) and I (3), have been isolated from octocoral Isis hippuris collected off the waters of Taiwan. The structure of steroid 1 was deduced by extensive 1D and 2D NMR studies. The absolute stereochemistry of steroids 1–3 was determined by single-crystal X-ray diffraction analysis. Steroid 2 exhibited cytotoxic effect against HT-29 and DLD-1 cancer cells with IC₅₀ values of 11.39 and 12.86 μM, respectively.

Original language	English
Article number	154142
Journal	Tetrahedron Letters
Volume	108
DOIs	https://doi.org/10.1016/j.tetlet.2022.154142
State	Published - 12 10 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

Cytotoxicity
Hippuristeroketal
Hippuristerone
Isis hippuris
X-ray

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2022.154142

Cite this

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title = "17,20-Epoxysteroids from octocoral Isis hippuris (Linnaeus, 1758)",

abstract = "Three 17,20-epoxysteroids, including a new metabolite, hippuristeroketal B (1), as well as two known compounds, hippuristerones A (2) and I (3), have been isolated from octocoral Isis hippuris collected off the waters of Taiwan. The structure of steroid 1 was deduced by extensive 1D and 2D NMR studies. The absolute stereochemistry of steroids 1–3 was determined by single-crystal X-ray diffraction analysis. Steroid 2 exhibited cytotoxic effect against HT-29 and DLD-1 cancer cells with IC50 values of 11.39 and 12.86 μM, respectively.",

keywords = "Cytotoxicity, Hippuristeroketal, Hippuristerone, Isis hippuris, X-ray",

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year = "2022",

month = oct,

day = "12",

doi = "10.1016/j.tetlet.2022.154142",

language = "英语",

volume = "108",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - 17,20-Epoxysteroids from octocoral Isis hippuris (Linnaeus, 1758)

AU - Huang, Yi Qi

AU - Chen, Po Jen

AU - Yang, San Nan

AU - Chien, Su Ying

AU - Zheng, Li Guo

AU - Wen, Zhi Hong

AU - Kuo, Liang Mou

AU - Sung, Ping Jyun

PY - 2022/10/12

Y1 - 2022/10/12

N2 - Three 17,20-epoxysteroids, including a new metabolite, hippuristeroketal B (1), as well as two known compounds, hippuristerones A (2) and I (3), have been isolated from octocoral Isis hippuris collected off the waters of Taiwan. The structure of steroid 1 was deduced by extensive 1D and 2D NMR studies. The absolute stereochemistry of steroids 1–3 was determined by single-crystal X-ray diffraction analysis. Steroid 2 exhibited cytotoxic effect against HT-29 and DLD-1 cancer cells with IC50 values of 11.39 and 12.86 μM, respectively.

AB - Three 17,20-epoxysteroids, including a new metabolite, hippuristeroketal B (1), as well as two known compounds, hippuristerones A (2) and I (3), have been isolated from octocoral Isis hippuris collected off the waters of Taiwan. The structure of steroid 1 was deduced by extensive 1D and 2D NMR studies. The absolute stereochemistry of steroids 1–3 was determined by single-crystal X-ray diffraction analysis. Steroid 2 exhibited cytotoxic effect against HT-29 and DLD-1 cancer cells with IC50 values of 11.39 and 12.86 μM, respectively.

KW - Cytotoxicity

KW - Hippuristeroketal

KW - Hippuristerone

KW - Isis hippuris

KW - X-ray

UR - https://www.scopus.com/pages/publications/85138183706

U2 - 10.1016/j.tetlet.2022.154142

DO - 10.1016/j.tetlet.2022.154142

M3 - 文章

AN - SCOPUS:85138183706

SN - 0040-4039

VL - 108

JO - Tetrahedron Letters

JF - Tetrahedron Letters

M1 - 154142

ER -

17,20-Epoxysteroids from octocoral Isis hippuris (Linnaeus, 1758)

Abstract

Bibliographical note

Keywords

UN SDGs

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