2-Acetoxybriaranes from Briareum violaceum

Jia Wen Yao; Wei Chiung Chi; Gene Hsiang Lee; Jui Hsin Su; Tsong Long Hwang; Yu Jen Wu; Tzu Rong Su; Jyh Horng Sheu; Ping Jyun Sung

doi:10.1016/j.tet.2019.05.053

2-Acetoxybriaranes from Briareum violaceum

Jia Wen Yao, Wei Chiung Chi, Gene Hsiang Lee, Jui Hsin Su, Tsong Long Hwang, Yu Jen Wu, Tzu Rong Su, Jyh Horng Sheu, Ping Jyun Sung^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

Five 2-acetoxybriaranes, including two known analogues, excavatolides B (1), E (2), along with three new metabolites, briaviolides V–X (3–5), have been obtained from the octocoral Briareum violaceum. The absolute configurations of 1 and 2 were determined by X-ray analysis for the first time and the structures of 3–5 were established by spectroscopic methods. Bioactivity study showed that briarane 3 decreased the release of elastase from human neutrophils.

Original language	English
Pages (from-to)	3751-3757
Number of pages	7
Journal	Tetrahedron
Volume	75
Issue number	27
DOIs	https://doi.org/10.1016/j.tet.2019.05.053
State	Published - 05 07 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

Briareum violaceum
Briaviolide
Elastase
Excavatolide

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10.1016/j.tet.2019.05.053

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title = "2-Acetoxybriaranes from Briareum violaceum",

abstract = "Five 2-acetoxybriaranes, including two known analogues, excavatolides B (1), E (2), along with three new metabolites, briaviolides V–X (3–5), have been obtained from the octocoral Briareum violaceum. The absolute configurations of 1 and 2 were determined by X-ray analysis for the first time and the structures of 3–5 were established by spectroscopic methods. Bioactivity study showed that briarane 3 decreased the release of elastase from human neutrophils.",

keywords = "Briareum violaceum, Briaviolide, Elastase, Excavatolide",

author = "Yao, {Jia Wen} and Chi, {Wei Chiung} and Lee, {Gene Hsiang} and Su, {Jui Hsin} and Hwang, {Tsong Long} and Wu, {Yu Jen} and Su, {Tzu Rong} and Sheu, {Jyh Horng} and Sung, {Ping Jyun}",

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year = "2019",

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doi = "10.1016/j.tet.2019.05.053",

language = "英语",

volume = "75",

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T1 - 2-Acetoxybriaranes from Briareum violaceum

AU - Yao, Jia Wen

AU - Chi, Wei Chiung

AU - Lee, Gene Hsiang

AU - Su, Jui Hsin

AU - Hwang, Tsong Long

AU - Wu, Yu Jen

AU - Su, Tzu Rong

AU - Sheu, Jyh Horng

AU - Sung, Ping Jyun

PY - 2019/7/5

Y1 - 2019/7/5

N2 - Five 2-acetoxybriaranes, including two known analogues, excavatolides B (1), E (2), along with three new metabolites, briaviolides V–X (3–5), have been obtained from the octocoral Briareum violaceum. The absolute configurations of 1 and 2 were determined by X-ray analysis for the first time and the structures of 3–5 were established by spectroscopic methods. Bioactivity study showed that briarane 3 decreased the release of elastase from human neutrophils.

AB - Five 2-acetoxybriaranes, including two known analogues, excavatolides B (1), E (2), along with three new metabolites, briaviolides V–X (3–5), have been obtained from the octocoral Briareum violaceum. The absolute configurations of 1 and 2 were determined by X-ray analysis for the first time and the structures of 3–5 were established by spectroscopic methods. Bioactivity study showed that briarane 3 decreased the release of elastase from human neutrophils.

KW - Briareum violaceum

KW - Briaviolide

KW - Elastase

KW - Excavatolide

UR - http://www.scopus.com/inward/record.url?scp=85066263182&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2019.05.053

DO - 10.1016/j.tet.2019.05.053

M3 - 文章

AN - SCOPUS:85066263182

SN - 0040-4020

VL - 75

SP - 3751

EP - 3757

JO - Tetrahedron

JF - Tetrahedron

IS - 27

ER -

2-Acetoxybriaranes from Briareum violaceum

Abstract

Bibliographical note

Keywords

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