2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

Pei Wen Hsieh; Fang Rong Chang; Cheng Hsien Chang; Pei Wen Cheng; Lien Chai Chiang; Fu Long Zeng; Kuei Hsiang Lin; Yang Chang Wu

doi:10.1016/j.bmcl.2004.06.083

2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

Pei Wen Hsieh, Fang Rong Chang, Cheng Hsien Chang, Pei Wen Cheng, Lien Chai Chiang, Fu Long Zeng, Kuei Hsiang Lin, Yang Chang Wu

Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

52 Scopus citations

Abstract

A series of 2-substituted benzoxazinones were synthesized and showed significant effect to anti-human coronavirus and ICAM-1 expression inhibition. A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC ₅₀ value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED ₅₀ values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively.

Original language	English
Pages (from-to)	4751-4754
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2004.06.083
State	Published - 20 09 2004
Externally published	Yes

Keywords

Anti-HCoVs
Benzoxazinones
ICAM-1

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10.1016/j.bmcl.2004.06.083

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title = "2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents",

abstract = "A series of 2-substituted benzoxazinones were synthesized and showed significant effect to anti-human coronavirus and ICAM-1 expression inhibition. A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC 50 value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED 50 values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively.",

keywords = "Anti-HCoVs, Benzoxazinones, ICAM-1",

author = "Hsieh, {Pei Wen} and Chang, {Fang Rong} and Chang, {Cheng Hsien} and Cheng, {Pei Wen} and Chiang, {Lien Chai} and Zeng, {Fu Long} and Lin, {Kuei Hsiang} and Wu, {Yang Chang}",

year = "2004",

month = sep,

day = "20",

doi = "10.1016/j.bmcl.2004.06.083",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

AU - Hsieh, Pei Wen

AU - Chang, Fang Rong

AU - Chang, Cheng Hsien

AU - Cheng, Pei Wen

AU - Chiang, Lien Chai

AU - Zeng, Fu Long

AU - Lin, Kuei Hsiang

AU - Wu, Yang Chang

PY - 2004/9/20

Y1 - 2004/9/20

N2 - A series of 2-substituted benzoxazinones were synthesized and showed significant effect to anti-human coronavirus and ICAM-1 expression inhibition. A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC 50 value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED 50 values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively.

AB - A series of 2-substituted benzoxazinones were synthesized and showed significant effect to anti-human coronavirus and ICAM-1 expression inhibition. A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC 50 value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED 50 values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively.

KW - Anti-HCoVs

KW - Benzoxazinones

KW - ICAM-1

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U2 - 10.1016/j.bmcl.2004.06.083

DO - 10.1016/j.bmcl.2004.06.083

M3 - 文章

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AN - SCOPUS:8544252430

SN - 0960-894X

VL - 14

SP - 4751

EP - 4754

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

Abstract

Keywords

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