2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

Pei Wen Hsieh; Fang Rong Chang; Cheng Hsien Chang; Pei Wen Cheng; Lien Chai Chiang; Fu Long Zeng; Kuei Hsiang Lin; Yang Chang Wu

doi:10.1016/j.bmcl.2004.06.083

2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

Pei Wen Hsieh
, Fang Rong Chang
, Cheng Hsien Chang
, Pei Wen Cheng
, Lien Chai Chiang
, Fu Long Zeng
, Kuei Hsiang Lin
, Yang Chang Wu

Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

55 Scopus citations

Abstract

A series of 2-substituted benzoxazinones were synthesized and showed significant effect to anti-human coronavirus and ICAM-1 expression inhibition. A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC ₅₀ value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED ₅₀ values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively.

Original language	English
Pages (from-to)	4751-4754
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2004.06.083
State	Published - 20 09 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-HCoVs
Benzoxazinones
ICAM-1

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10.1016/j.bmcl.2004.06.083

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title = "2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents",

abstract = "A series of 2-substituted benzoxazinones were synthesized and showed significant effect to anti-human coronavirus and ICAM-1 expression inhibition. A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC 50 value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED 50 values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively.",

keywords = "Anti-HCoVs, Benzoxazinones, ICAM-1",

author = "Hsieh, \{Pei Wen\} and Chang, \{Fang Rong\} and Chang, \{Cheng Hsien\} and Cheng, \{Pei Wen\} and Chiang, \{Lien Chai\} and Zeng, \{Fu Long\} and Lin, \{Kuei Hsiang\} and Wu, \{Yang Chang\}",

year = "2004",

month = sep,

day = "20",

doi = "10.1016/j.bmcl.2004.06.083",

language = "英语",

volume = "14",

pages = "4751--4754",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

AU - Hsieh, Pei Wen

AU - Chang, Fang Rong

AU - Chang, Cheng Hsien

AU - Cheng, Pei Wen

AU - Chiang, Lien Chai

AU - Zeng, Fu Long

AU - Lin, Kuei Hsiang

AU - Wu, Yang Chang

PY - 2004/9/20

Y1 - 2004/9/20

N2 - A series of 2-substituted benzoxazinones were synthesized and showed significant effect to anti-human coronavirus and ICAM-1 expression inhibition. A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC 50 value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED 50 values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively.

AB - A series of 2-substituted benzoxazinones were synthesized and showed significant effect to anti-human coronavirus and ICAM-1 expression inhibition. A series of 2-substituted benzoxazinones were synthesized and subjected to anti-human coronavirus and ICAM-1 expression inhibition assays. Among them, compounds 1, 3, 4, 5, 6, and 7 exhibited significant anti-HCoV activities, and the IC 50 value of these compounds are 6.08, 5.06, 6.83, 1.92, 7.59, and 5.79 μg/mL, respectively. Furthermore, compounds 1 and 6 showed significant inhibitory effect on ICAM-1 expression, the ED 50 values of 1 and 6 are 1.00 and 0.50 μg/mL, respectively.

KW - Anti-HCoVs

KW - Benzoxazinones

KW - ICAM-1

UR - https://www.scopus.com/pages/publications/8544252430

U2 - 10.1016/j.bmcl.2004.06.083

DO - 10.1016/j.bmcl.2004.06.083

M3 - 文章

C2 - 15324901

AN - SCOPUS:8544252430

SN - 0960-894X

VL - 14

SP - 4751

EP - 4754

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents

Abstract

UN SDGs

Keywords

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