6-Gingerol inhibits ROS and iNOS through the suppression of PKC-α and NF-κB pathways in lipopolysaccharide-stimulated mouse macrophages

Tzung Yan Lee*, Ko Chen Lee, Shih Yuan Chen, Hen Hong Chang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

133 Scopus citations

Abstract

Inflammation is involved in numerous diseases, including chronic inflammatory diseases and the development of cancer. Many plants possess a variety of biological activities, including antifungal, antibacterial and anti-inflammatory activities. However, our understanding of the anti-inflammatory effects of 6-gingerol is very limited. We used lipopolysaccharide (LPS)-stimulated macrophages as a model of inflammation to investigate the anti-inflammatory effects of 6-gingerol, which contains phenolic structure. We found that 6-gingerol exhibited an anti-inflammatory effect. 6-Gingerol could decrease inducible nitric oxide synthase and TNF-α expression through suppression of I-κBα phosphorylation, NF-κB nuclear activation and PKC-α translocation, which in turn inhibits Ca2+ mobilization and disruption of mitochondrial membrane potential in LPS-stimulated macrophages. Here, we demonstrate that 6-gingerol acts as an anti-inflammatory agent by blocking NF-κB and PKC signaling, and may be developed as a useful agent for the chemoprevention of cancer or inflammatory diseases.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume382
Issue number1
DOIs
StatePublished - 24 04 2009

Keywords

  • 6-Gingerol
  • Lipopolysaccharide
  • NF-κB
  • iNOS

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