A 7-year surveillance for ESBL-producing Escherichia coli and Klebsiella pneumoniae at a university hospital in Taiwan: The increase of CTX-M-15 in the ICU

J. C. Shu, J. H. Chia, A. J. Kuo, L. H. Su, T. L. Wu

Research output: Contribution to journalJournal Article peer-review

24 Scopus citations

Abstract

To monitor the changing trend of extended-spectrum -lactamase (ESBL)-producing bacteria, a 7-year continuous study was launched in 2001 at the largest tertiary hospital in Taiwan. A significant increase over the study period was evident for ESBL-producing isolates of Escherichia coli (48-100%) and Klebsiella pneumoniae (150-234%). Molecular investigation conducted in three separate periods revealed the prevalent ESBL types and their genetic relatedness. CTX-M-producing isolates (738%) were more prevalent than SHV-type ESBLs (370%), the most frequent being CTX-M-14 (343%), CTX-M-3 (259%), and SHV-12 (257%). However, a marked increase of CTX-M-15-producing isolates from 21% in 2002 to 296% in 2007 was also noted. The increase of ESBL-producing isolates in both species may be mainly due to the horizontal transmission of resistance plasmids, while clonal expansion of some epidemic strains further added to the dispersion of ESBL-producing K. pneumoniae.

Original languageEnglish
Pages (from-to)253-263
Number of pages11
JournalEpidemiology and Infection
Volume138
Issue number2
DOIs
StatePublished - 02 2010

Keywords

  • CTX-M-15
  • ESBL
  • ICUs

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