A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process

  • Tushar Harishchandra Punde*
  • , Wen Hao Wu
  • , Pei Chun Lien
  • , Po Chen Shih
  • , Margaret Dah Tsyr Chang
  • , Kang Yun Lee
  • , Han Pin Kuo
  • , Cheng Hsien Liu
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We report a 3D biomimetic microsystem which mimics lung microenvironment for monitoring the role of chemokine induced lung inflammation. The extravasation of fibrocytes in response to eosinophil cationic protein (ECP)-stimulated bronchial epithelial cells induced lung inflammation was mimicked on the micro-fluidic chip system for monitoring the microenvironmental changes.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1021-1023
Number of pages3
ISBN (Print)9780979806452
StatePublished - 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 28 10 201201 11 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Country/TerritoryJapan
CityOkinawa
Period28/10/1201/11/12

Keywords

  • Biomimetics
  • Bronchial asthma
  • Eosinophil cationic protein
  • Fibrocytes
  • Microfluidic chip

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