A cell-patterning biochip based on dielectrophoresis for liver tissue application

C. T. Ho, P. C. Lin, H. Y. Chang, C. H. Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this paper, we report the design, microfabrication process and experimental results for rapidly rebuilding the cell pattern in a biochip. We pattern the liver cells via the design of a concentric-stellate-tips-electrodes array to mimic the real liver tissue. By constructing the geometric shape and the distribution of stellate tips, the functional electrodes could generated spatial electric-field gradient via the effect of field-induced dielectrophoresis to guide and control individual cells to the desired locations in a parallel process. Experiment result exhibits that the liver cells are positioned and aligned into a pearl chain array to form the liver-tissue-mimic pattern with good cell viability via a cell-patterning biochip.

Original languageEnglish
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages1368-1370
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - 2005
Externally publishedYes
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: 09 10 200513 10 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Conference

Conference9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
Country/TerritoryUnited States
CityBoston, MA
Period09/10/0513/10/05

Keywords

  • BioMEMS
  • Cell patterning
  • Dielectrophoresis

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