A comprehensive analysis of the association of common variants of ABCG2 with gout

Kuang Hui Yu; Pi Yueh Chang; Shih Cheng Chang; Yah Huei Wu-Chou; Li An Wu; Ding Pin Chen; Fu Sung Lo; Jang Jih Lu

doi:10.1038/s41598-017-10196-2

A comprehensive analysis of the association of common variants of ABCG2 with gout

Kuang Hui Yu, Pi Yueh Chang, Shih Cheng Chang, Yah Huei Wu-Chou, Li An Wu, Ding Pin Chen, Fu Sung Lo, Jang Jih Lu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

26 Scopus citations

Abstract

The objective of the present study was to determine whether there was an association between single nucleotide polymorphisms (SNPs) in ABCG2 and gout. We recruited 333 participants including 210 patients with gout and 123 controls and genotyped 45 SNPs in both cohorts. We found that 24 SNPs in ABCG2 are susceptibility loci associated with gout. Haplotype analysis revealed five blocks across the ABCG2 locus were associated with an increased risk of gout with odds ratios (ORs) from 2.59-3.17 (all P < 0.0001). A novel finding in the present study was the identification of rs3114018 in block 3 and its association with increased gout risk. We found that the rs2231142T allele in block 2 and the rs3114018C-rs3109823T (C-T) risk haplotype in block 3 conferred the greatest evidence of association to gout risk (P = 1.19 × 10^-12 and P = 9.20 × 10^-11, respectively). Our study provides an improved understanding of ABCG2 variations in patients with gout and, as shown by haplotype analysis, that ABCG2 may have a role in gout susceptibility.

Original language	English
Article number	9988
Journal	Scientific Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-10196-2
State	Published - 01 12 2017
Externally published	Yes

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title = "A comprehensive analysis of the association of common variants of ABCG2 with gout",

abstract = "The objective of the present study was to determine whether there was an association between single nucleotide polymorphisms (SNPs) in ABCG2 and gout. We recruited 333 participants including 210 patients with gout and 123 controls and genotyped 45 SNPs in both cohorts. We found that 24 SNPs in ABCG2 are susceptibility loci associated with gout. Haplotype analysis revealed five blocks across the ABCG2 locus were associated with an increased risk of gout with odds ratios (ORs) from 2.59-3.17 (all P < 0.0001). A novel finding in the present study was the identification of rs3114018 in block 3 and its association with increased gout risk. We found that the rs2231142T allele in block 2 and the rs3114018C-rs3109823T (C-T) risk haplotype in block 3 conferred the greatest evidence of association to gout risk (P = 1.19 × 10-12 and P = 9.20 × 10-11, respectively). Our study provides an improved understanding of ABCG2 variations in patients with gout and, as shown by haplotype analysis, that ABCG2 may have a role in gout susceptibility.",

author = "Yu, \{Kuang Hui\} and Chang, \{Pi Yueh\} and Chang, \{Shih Cheng\} and Wu-Chou, \{Yah Huei\} and Wu, \{Li An\} and Chen, \{Ding Pin\} and Lo, \{Fu Sung\} and Lu, \{Jang Jih\}",

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doi = "10.1038/s41598-017-10196-2",

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AU - Chang, Pi Yueh

AU - Chang, Shih Cheng

AU - Wu-Chou, Yah Huei

AU - Wu, Li An

AU - Chen, Ding Pin

AU - Lo, Fu Sung

AU - Lu, Jang Jih

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N2 - The objective of the present study was to determine whether there was an association between single nucleotide polymorphisms (SNPs) in ABCG2 and gout. We recruited 333 participants including 210 patients with gout and 123 controls and genotyped 45 SNPs in both cohorts. We found that 24 SNPs in ABCG2 are susceptibility loci associated with gout. Haplotype analysis revealed five blocks across the ABCG2 locus were associated with an increased risk of gout with odds ratios (ORs) from 2.59-3.17 (all P < 0.0001). A novel finding in the present study was the identification of rs3114018 in block 3 and its association with increased gout risk. We found that the rs2231142T allele in block 2 and the rs3114018C-rs3109823T (C-T) risk haplotype in block 3 conferred the greatest evidence of association to gout risk (P = 1.19 × 10-12 and P = 9.20 × 10-11, respectively). Our study provides an improved understanding of ABCG2 variations in patients with gout and, as shown by haplotype analysis, that ABCG2 may have a role in gout susceptibility.

AB - The objective of the present study was to determine whether there was an association between single nucleotide polymorphisms (SNPs) in ABCG2 and gout. We recruited 333 participants including 210 patients with gout and 123 controls and genotyped 45 SNPs in both cohorts. We found that 24 SNPs in ABCG2 are susceptibility loci associated with gout. Haplotype analysis revealed five blocks across the ABCG2 locus were associated with an increased risk of gout with odds ratios (ORs) from 2.59-3.17 (all P < 0.0001). A novel finding in the present study was the identification of rs3114018 in block 3 and its association with increased gout risk. We found that the rs2231142T allele in block 2 and the rs3114018C-rs3109823T (C-T) risk haplotype in block 3 conferred the greatest evidence of association to gout risk (P = 1.19 × 10-12 and P = 9.20 × 10-11, respectively). Our study provides an improved understanding of ABCG2 variations in patients with gout and, as shown by haplotype analysis, that ABCG2 may have a role in gout susceptibility.

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A comprehensive analysis of the association of common variants of ABCG2 with gout

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